Nina Medical Ltd.

Nina Medical Ltd., founded in January 2019, is a health-tech company operating out of Nazareth, Israel, focused on developing a non-invasive treatment for Benign Prostatic Hyperplasia (BPH). The company was co-founded by CEO Shmuel Ben-Ezra and CTO Yoni Hertzberg. Mr. Ben-Ezra brings over two decades of experience from the high-tech industry, primarily in medical technology.

The company is addressing a significant market need, as BPH affects over half of men over the age of 50. Current treatments beyond medication are often invasive, involving transurethral procedures, which leads many men to delay or avoid treatment altogether. Nina Medical aims to capture a substantial portion of this underserved market by offering a completely non-invasive alternative that can be administered in a urologist's office.

The core of Nina Medical's business is its proprietary LOTUS-1 system, a diagnostic-therapeutic device that combines high-intensity focused ultrasound (HIFU) for thermal ablation with diagnostic ultrasound for imaging. This technology is delivered via a transperineal approach, utilizing the perineum as an acoustic window to access the prostate. A key feature is the ability to visualize the focal point of the therapeutic beam within the body in real-time, enhancing safety and precision during the tissue ablation process. The entire procedure is conducted while the patient is in a natural sitting position, designed to improve comfort and reduce the psychological barriers associated with conventional methods.

As a seed-stage company, Nina Medical has secured approximately $3.17 million in total funding through multiple rounds, with support from investors such as NGT3 VC, the Israel Innovation Authority, and private backers. The company has completed animal trials and a preliminary clinical study with 20 patients, and is now preparing for further first-in-human clinical trials.

Keywords: Benign Prostatic Hyperplasia, BPH treatment, non-invasive surgery, HIFU, high-intensity focused ultrasound, thermal ablation, ultrasound imaging, urology, med-tech, transperineal therapy, medical device, prostate health, image-guided therapy, LOTUS-1 system, Shmuel Ben-Ezra, Yoni Hertzberg, Israel Innovation Authority, Health Tech, Life Sciences, men's health