Endo Tools Therapeutics

Endo Tools Therapeutics (ETT) is a Belgian medical device company, established in 2008 as a spin-off from the Université libre de Bruxelles. The company's foundation is built upon a collaborative effort between engineers from the university's engineering school and gastroenterologists at Erasme Hospital.

The company operates in the field of interventional gastroenterology, developing devices that facilitate minimally invasive procedures. Its primary clients are gastroenterologists and surgeons in hospitals and specialized clinics. The business model centers on the development and sale of these advanced medical devices. ETT has successfully raised a total of $18.7 million over three funding rounds, with the latest being a Series D round of $9.66 million in January 2021, led by White Fund.

ETT's flagship product is the endomina® system, designed for the endoscopic placement of sutures and the approximation of soft tissue within the gastrointestinal tract. This system features a universal triangulation platform and an instrument for tissue piercing and approximation (TAPES), which can be attached to standard endoscopes. This technology provides a bendable, independently movable therapeutic channel, allowing physicians to perform complex suturing procedures similar to laparoscopy but through a natural orifice, eliminating the need for external incisions. The system is engineered to be assembled on the endoscope within the stomach, creating a larger working space.

Significant milestones for the company include obtaining the CE mark for its devices in 2015, which permitted commercialization in Europe. More recently, the company secured 510(k) clearance from the U.S. Food and Drug Administration (FDA) in January 2022, enabling its entry into the U.S. market. The first commercial procedures in the United States were performed in August 2022. The endomina® system has been used in over 500 procedures globally and has also received EU MDR certification, a stricter regulatory standard. The technology is being studied for a range of applications, including bariatric interventions, Gastroesophageal Reflux Disease (GERD), and Endoscopic Full Thickness Resection (EFTR).

Keywords: endoscopic suturing, interventional gastroenterology, medical devices, minimally invasive surgery, triangulation platform, tissue approximation, natural orifice surgery, gastrointestinal procedures, endomina, flexible endoscopy, bariatric interventions, GERD treatment, endoscopic resection, incisionless surgery, medtech, therapeutic endoscopy, gastroenterology devices, soft tissue approximation, full-thickness suture, advanced endoscopy