Cytovia Therapeutics
Develops transformational cancer immunotherapies and addresses several unmet medical needs for cancer prevention.
| Date | Investors | Amount | Round |
|---|---|---|---|
| investor investor | €0.0 | round | |
| investor | €0.0 Valuation: €0.0 | round | |
* | N/A | $20.0m Valuation: $602m | SPAC Private Placement |
| Total Funding | 000k | ||
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Cytovia Therapeutics, Inc., established in 2019, is a clinical-stage biopharmaceutical company focused on the development of allogeneic "off-the-shelf" gene-edited iPSC-derived Natural Killer (NK) and Chimeric Antigen Receptor (CAR)-NK cells. The company's core mission is to develop complementary cancer immunotherapies aimed at addressing the limitations of current cancer treatments. Cytovia was co-founded by Dr. Daniel Teper, who also serves as the Chairman and CEO, and the company maintains operations in Aventura, Florida, and Natick, Massachusetts. Dr. Teper brings extensive experience to the firm, having previously co-founded and led several life sciences companies, including Immune Pharmaceuticals and N pharma.
The company's technological foundation is built upon induced Pluripotent Stem Cells (iPSCs), which are utilized to create a consistent and scalable supply of NK cells. This approach allows for the production of standardized, cryopreserved therapies that can be made readily available for patient treatment. Cytovia's proprietary TALEN gene-editing technology, licensed from Cellectis, is employed to enhance the persistence and effectiveness of its cell therapies against cancer. Specifically, the technology can be used to prevent graft-versus-host disease (GvHD), overcome tumor microenvironment resistance, and improve the cells' targeting capabilities.
The development pipeline at Cytovia features several product candidates, including CYT-100, which utilizes unmodified iPSC-derived NK cells, and CYT-303, an iPSC-derived NK cell therapy targeting GPC3 for hepatocellular carcinoma. Another key asset is CYT-503, a CD38-targeting CAR-iNK product candidate being developed for multiple myeloma in collaboration with Cellectis. The company's business model revolves around advancing these candidates through clinical trials and ultimately securing regulatory approval for commercialization. Cytovia has engaged in strategic partnerships, such as its collaboration with the New York Stem Cell Foundation to create a cGMP iPSC master cell bank and its licensing agreement with Cellectis for gene-editing technologies. Keywords: immunotherapy, CAR-NK, iPSC, cell therapy, oncology, biopharmaceutical, gene-editing, natural killer cells, cancer treatment, clinical-stage