Base Pair Biotechnologies

Base Pair Biotechnologies, Inc., established in 2012, operates within the biotechnology sector, specializing in the development of synthetic nucleic acid affinity ligands known as aptamers. The company was founded by Dr. Bill Jackson, who brings over two decades of experience in molecular biology and diagnostics to the firm. His background includes extensive work in developing platform technologies for life science research and diagnostics, which directly informs the company's core mission. The genesis of Base Pair Biotechnologies stemmed from the recognition that traditional antibodies, while widely used, have limitations that aptamers can overcome, such as higher stability and lower production costs.

The company's primary business involves the rapid discovery and development of custom aptamers for a diverse clientele that includes academic researchers, diagnostic companies, and therapeutic developers. Revenue is generated through a fee-for-service model, where clients contract Base Pair for specific aptamer development projects. This process leverages a proprietary, multiplexed selection technology, which allows for the simultaneous screening of aptamers against multiple targets, significantly accelerating the discovery timeline. This patented method is a key differentiator, enabling the identification of high-affinity, high-specificity aptamers more efficiently than conventional selection techniques.

The core service is centered around creating these single-stranded DNA or RNA molecules that bind to a wide array of targets, from small molecules to large proteins and even whole cells. These aptamers function as synthetic antibodies and can be utilized in various applications, including diagnostic assays (like ELISA-type tests), biosensors, therapeutics, and targeted drug delivery. The benefits of using aptamers over antibodies include their chemical synthesis, which ensures high batch-to-batch consistency, their stability under a range of temperatures and conditions, and the ability to be chemically modified to enhance their functional properties. Base Pair Biotechnologies provides a comprehensive service that covers the entire workflow from initial selection to final characterization and validation of the aptamer for the client's specific application.

Keywords: aptamer discovery, synthetic antibodies, affinity ligands, biotechnology, diagnostics, nucleic acid, life science research, drug delivery, biosensors, molecular biology